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The Palestinian American Chamber of Commerce (AmCham-Palestine) is a member of the United States Chamber of Commerce and AmCham MENA Council. It was founded in 1997 as a non-profit membership-based organization by a group of private sector leaders in Palestine, with the aim of serving the Palestinian and American business communities and contributing to the development of the commercial activities between the Palestinian Territories and the United States of America.

AmCham-Palestine is regarded to be the national platform for Palestinian-American business relations, representing leading companies in all sectors that joined forces to make an economic difference. Currently, AmCham-Palestine is playing a crucial role in promoting business relations and partnerships between Palestine and American businesses believing that this role leads to economic growth, technology transfer and job creation in Palestine.

AmCham-Palestine membership stands at over 80 top and leading Palestinian and American companies representing nine main sectors in Palestine.